Disease associated perturbations of H/ACA small RNA activity reveal a functional role for specialized RNA modifications in hematopoietic stem cell differentiation

Noncoding RNAs control critical cellular processes, although their contribution to disease remains largely unexplored. Dyskerin associates with hundreds of H/ACA small RNAs to generate a multitude of functionally distinct ribonucleoproteins (RNPs). The DKC1 gene, encoding dyskerin, is mutated in the...

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Autors principals: Bellodi, Cristian, McMahon, Mary, Contreras, Adrian, Juliano, Dayle, Kopmar, Noam, Nakamura, Tomoka, Maltby, David, Burlingame, Alma, Savage, Sharon A., Shimamura, Akiko, Ruggero, Davide
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3857015/
https://ncbi.nlm.nih.gov/pubmed/23707062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.030
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