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A wobbly road to drug resistance in melanoma: tRNA‐modifying enzymes in translation reprogramming

Alterations in transcript‐specific translation are emerging as a driver of cellular transformation and cancer etiology. A new study provides evidence for enhanced codon‐dependent translation of hypoxia‐inducible factor 1α in promoting glycolytic metabolism and drug resistance in melanoma cells. This...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: McMahon, Mary, Ruggero, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6068441/
https://ncbi.nlm.nih.gov/pubmed/29967029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899978
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