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A novel computer algorithm improves antibody epitope prediction using affinity-selected mimotopes: A case study using monoclonal antibodies against the West Nile virus E protein

Understanding antibody function is often enhanced by knowledge of the specific binding epitope. Here, we describe a computer algorithm that permits epitope prediction based on a collection of random peptide epitopes (mimotopes) isolated by antibody affinity purification. We applied this methodology...

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Detalhes bibliográficos
Main Authors: Denisova, Galina F., Denisov, Dimitri A., Yeung, Jeffrey, Loeb, Mark B., Diamond, Michael S., Bramson, Jonathan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856767/
https://ncbi.nlm.nih.gov/pubmed/18760481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2008.07.020
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