RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

BACKGROUND: A major obstacle in treating colorectal cancer (CRC) is the acquired resistance to chemotherapeutic agents. An important protein in the regulation of cancer cell death and clinical outcome is Raf kinase inhibitor protein (RKIP). In contrast, activated signal transducer and activator of t...

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Bibliografiska uppgifter
Huvudupphovsmän: Cross-Knorr, Sam, Lu, Shaolei, Perez, Kimberly, Guevara, Sara, Brilliant, Kate, Pisano, Claudio, Quesenberry, Peter J, Resnick, Murray B, Chatterjee, Devasis
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856511/
https://ncbi.nlm.nih.gov/pubmed/24098947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-463
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