RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients

BACKGROUND: A major obstacle in treating colorectal cancer (CRC) is the acquired resistance to chemotherapeutic agents. An important protein in the regulation of cancer cell death and clinical outcome is Raf kinase inhibitor protein (RKIP). In contrast, activated signal transducer and activator of t...

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Bibliografske podrobnosti
Main Authors: Cross-Knorr, Sam, Lu, Shaolei, Perez, Kimberly, Guevara, Sara, Brilliant, Kate, Pisano, Claudio, Quesenberry, Peter J, Resnick, Murray B, Chatterjee, Devasis
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3856511/
https://ncbi.nlm.nih.gov/pubmed/24098947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-463
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