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The Dynamics of Signaling as a Pharmacological Target
Highly networked signaling hubs are often associated with disease, but targeting them pharmacologically has largely been unsuccessful in the clinic because of their functional pleiotropy. Motivated by the hypothesis that a dynamical signaling code confers functional specificity, we investigated whet...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3856316/ https://ncbi.nlm.nih.gov/pubmed/24120141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.09.018 |
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