Racial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c

Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n = 70) and white (n = 84) subjects. PAR4 thrombin receptor induced platelet aggregation and calcium mobilization were significantly greater...

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Autori principali: Edelstein, Leonard C., Simon, Lukas M., Montoya, Raúl Teruel, Holinstat, Michael, Chen, Edward S., Bergeron, Angela, Kong, Xianguo, Nagalla, Srikanth, Mohandas, Narla, Cohen, David E., Dong, Jing-fei, Shaw, Chad, Bray, Paul F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855898/
https://ncbi.nlm.nih.gov/pubmed/24216752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3385
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