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Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis
NF-κB is a key transcription factor that regulates innate immune response. Its activity is tightly controlled by numerous feedback loops, including two negative loops mediated by NF-κB inducible inhibitors, IκBα and A20, which assure oscillatory responses, and by positive feedback loops arising due...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3855823/ https://ncbi.nlm.nih.gov/pubmed/24324544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078887 |
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