Importins promote high-frequency NF-κB oscillations increasing information channel capacity

BACKGROUND: Importins and exportins influence gene expression by enabling nucleocytoplasmic shuttling of transcription factors. A key transcription factor of innate immunity, NF-κB, is sequestered in the cytoplasm by its inhibitor, IκBα, which masks nuclear localization sequence of NF-κB. In respons...

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Bibliografische gegevens
Gepubliceerd in:Biol Direct
Hoofdauteurs: Korwek, Zbigniew, Tudelska, Karolina, Nałęcz-Jawecki, Paweł, Czerkies, Maciej, Prus, Wiktor, Markiewicz, Joanna, Kochańczyk, Marek, Lipniacki, Tomasz
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
Onderwerpen:
Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5106790/
https://ncbi.nlm.nih.gov/pubmed/27835978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13062-016-0164-z
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