HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4(+) T Cells In Vivo

The precise role of viral protein R (Vpr), an HIV-1-encoded protein, during HIV-1 infection and its contribution to the development of AIDS remain unclear. Previous reports have shown that Vpr has the ability to cause G(2) cell cycle arrest and apoptosis in HIV-1-infected cells in vitro. In addition...

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Detalhes bibliográficos
Main Authors: Sato, Kei, Misawa, Naoko, Iwami, Shingo, Satou, Yorifumi, Matsuoka, Masao, Ishizaka, Yukihito, Ito, Mamoru, Aihara, Kazuyuki, An, Dong Sung, Koyanagi, Yoshio
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855622/
https://ncbi.nlm.nih.gov/pubmed/24339781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003812
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