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Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial Pnkp•Hen1 RNA repair system

Clostridium thermocellum Pnkp is the end-healing and end-sealing subunit of a bacterial RNA repair system. CthPnkp is composed of three catalytic modules: an N-terminal 5′-OH polynucleotide kinase; a central 2′,3′ phosphatase; and a C-terminal ligase. The crystal structure of the kinase domain bound...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Das, Ushati, Wang, Li Kai, Smith, Paul, Shuman, Stewart
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855621/
https://ncbi.nlm.nih.gov/pubmed/23721485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400412x
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