Combining Regulatory T Cell Depletion and Inhibitory Receptor Blockade Improves Reactivation of Exhausted Virus-Specific CD8(+) T Cells and Efficiently Reduces Chronic Retroviral Loads

Chronic infections with human viruses, such as HIV and HCV, or mouse viruses, such as LCMV or Friend Virus (FV), result in functional exhaustion of CD8(+) T cells. Two main mechanisms have been described that mediate this exhaustion: expression of inhibitory receptors on CD8(+) T cells and expansion...

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Bibliographic Details
Main Authors: Dietze, Kirsten K., Zelinskyy, Gennadiy, Liu, Jia, Kretzmer, Freya, Schimmer, Simone, Dittmer, Ulf
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855586/
https://ncbi.nlm.nih.gov/pubmed/24339778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003798
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