A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells

PD-1-targeted therapies have shown modest antiviral effects in preclinical models of chronic viral infection. Thus, novel therapy protocols are necessary to enhance T cell immunity and viral control to overcome T cell dysfunction and immunosuppression. Here, we demonstrate that nanoparticle-based th...

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Vydáno v:mBio
Hlavní autoři: Knuschke, Torben, Kollenda, Sebastian, Wenzek, Christina, Zelinskyy, Gennadiy, Steinbach, Philine, Dittmer, Ulf, Buer, Jan, Epple, Matthias, Westendorf, Astrid M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858051/
https://ncbi.nlm.nih.gov/pubmed/33531395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02121-20
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