Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8(+) T cells and reduces chronic retroviral set points

Although chronic infections with viruses such as HIV and hepatitis C virus have been associated with regulatory T cell (Treg)-mediated suppression of virus-specific CD8(+) T-cell activity, no causal relationship between Tregs and chronic viral set points has been established. Using transgenic mice i...

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Detalhes bibliográficos
Main Authors: Dietze, Kirsten K., Zelinskyy, Gennadiy, Gibbert, Kathrin, Schimmer, Simone, Francois, Sandra, Myers, Lara, Sparwasser, Tim, Hasenkrug, Kim J., Dittmer, Ulf
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3038736/
https://ncbi.nlm.nih.gov/pubmed/21262821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015148108
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