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Optimization of Tet1 ligand density in HPMA-co-oligolysine copolymers for targeted neuronal gene delivery

Targeted gene delivery vectors can enhance cellular specificity and transfection efficiency. We demonstrated previously that conjugation of Tet1, a peptide that binds to the GT1b ganglioside, to polyethylenimine results in preferential transfection of neural progenitor cells in vivo. In this work, w...

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Hlavní autoři: Chu, David S.H., Schellinger, Joan G., Bocek, Michael J., Johnson, Russell N., Pun, Suzie H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855292/
https://ncbi.nlm.nih.gov/pubmed/24041424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.08.045
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