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The Proteasome Inhibitor Bortezomib Induces an Inhibitory Chromatin Environment at a Distal Enhancer of the Estrogen Receptor-α Gene

Expression of the estrogen receptor-α (ERα) gene, ESR1, is a clinical biomarker used to predict therapeutic outcome of breast cancer. Hence, there is significant interest in understanding the mechanisms regulating ESR1 gene expression. Proteasome activity is increased in cancer and we previously sho...

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Detalles Bibliográficos
Main Authors: Powers, Ginny L., Rajbhandari, Prashant, Solodin, Natalia M., Bickford, Brant, Alarid, Elaine T.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855213/
https://ncbi.nlm.nih.gov/pubmed/24339902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081110
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