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The Proteasome Inhibitor Bortezomib Induces an Inhibitory Chromatin Environment at a Distal Enhancer of the Estrogen Receptor-α Gene

Expression of the estrogen receptor-α (ERα) gene, ESR1, is a clinical biomarker used to predict therapeutic outcome of breast cancer. Hence, there is significant interest in understanding the mechanisms regulating ESR1 gene expression. Proteasome activity is increased in cancer and we previously sho...

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Main Authors: Powers, Ginny L., Rajbhandari, Prashant, Solodin, Natalia M., Bickford, Brant, Alarid, Elaine T.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855213/
https://ncbi.nlm.nih.gov/pubmed/24339902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081110
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