Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study

Amyloid β-peptide (Aβ) plays a central role in pathophysiology of Alzheimer’s disease (AD) through the induction of oxidative stress. This peptide is produced by proteolytic cleavage of amyloid precursor protein (APP) by the action of β- and γ-secretases. Previous studies demonstrated that reduction...

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Main Authors: Fiorini, Ada, Sultana, Rukhsana, Förster, Sarah, Perluigi, Marzia, Cenini, Giovanna, Cini, Chiara, Cai, Jian, Klein, Jon B., Farr, Susan A., Niehoff, Michael L., Morley, John E., Kumar, Vijaya B., Butterfield, D. Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855183/
https://ncbi.nlm.nih.gov/pubmed/23777706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.06.017
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