Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women

BACKGROUND: Previous studies carried out in our laboratories have demonstrated impaired drug permeation in diabetic animals. In this study the permeation of diazepam (after a single dose of 5 mg/day, administered intramuscularly) will be investigated in diabetic and hypertensive pregnant women. METH...

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Autori principali: Lalic-Popovic, Mladena, Paunkovic, Jovana, Grujic, Zorica, Golocorbin-Kon, Svetlana, Al-Salami, Hani, Mikov, Momir
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854538/
https://ncbi.nlm.nih.gov/pubmed/24134697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2393-13-188
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