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Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin–reactivating agent hydroxyurea are currently the mainstay of treatment. Discoveries over the past 2 decades have highlighte...

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Hlavní autoři: Manwani, Deepa, Frenette, Paul S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854110/
https://ncbi.nlm.nih.gov/pubmed/24052549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-498311
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