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Structural Bioinformatics and Protein Docking Analysis of the Molecular Chaperone-Kinase Interactions: Towards Allosteric Inhibition of Protein Kinases by Targeting the Hsp90-Cdc37 Chaperone Machinery

A fundamental role of the Hsp90-Cdc37 chaperone system in mediating maturation of protein kinase clients and supporting kinase functional activity is essential for the integrity and viability of signaling pathways involved in cell cycle control and organism development. Despite significant advances...

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Bibliografske podrobnosti
Main Authors: Lawless, Nathan, Blacklock, Kristin, Berrigan, Elizabeth, Verkhivker, Gennady
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3854018/
https://ncbi.nlm.nih.gov/pubmed/24287464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph6111407
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