Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system

Heterozygous mutations of the cardiac transcription factor Nkx2-5 cause atrioventricular conduction defects in humans by unknown mechanisms. We show in KO mice that the number of cells in the cardiac conduction system is directly related to Nkx2-5 gene dosage. Null mutant embryos appear to lack the...

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Main Authors: Jay, Patrick Y., Harris, Brett S., Maguire, Colin T., Buerger, Antje, Wakimoto, Hiroko, Tanaka, Makoto, Kupershmidt, Sabina, Roden, Dan M., Schultheiss, Thomas M., O’Brien, Terrence X., Gourdie, Robert G., Berul, Charles I., Izumo, Seigo
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2004
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC385399/
https://ncbi.nlm.nih.gov/pubmed/15085192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419846
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