Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system

Heterozygous mutations of the cardiac transcription factor Nkx2-5 cause atrioventricular conduction defects in humans by unknown mechanisms. We show in KO mice that the number of cells in the cardiac conduction system is directly related to Nkx2-5 gene dosage. Null mutant embryos appear to lack the...

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Hlavní autoři: Jay, Patrick Y., Harris, Brett S., Maguire, Colin T., Buerger, Antje, Wakimoto, Hiroko, Tanaka, Makoto, Kupershmidt, Sabina, Roden, Dan M., Schultheiss, Thomas M., O’Brien, Terrence X., Gourdie, Robert G., Berul, Charles I., Izumo, Seigo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC385399/
https://ncbi.nlm.nih.gov/pubmed/15085192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200419846
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