DIFFERENTIATION OF CARDIAC PURKINJE FIBERS REQUIRES PRECISE SPATIOTEMPORAL REGULATION OF Nkx2-5 EXPRESSION

Nkx2-5 gene mutations cause cardiac abnormalities including deficits of function in the atrioventricular conduction system (AVCS). In the chick, Nkx2-5 is elevated in Purkinje fiber AVCS cells relative to working cardiomyocytes. Here, we show that Nkx2-5 expression rises to a peak as Purkinje fibers...

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Detalhes bibliográficos
Main Authors: Harris, Brett S., Spruill, Laura, Edmonson, Angela M., Rackley, Mary S., Benson, D. Woodrow, O’Brien, Terrence X., Gourdie, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610391/
https://ncbi.nlm.nih.gov/pubmed/16245335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.20580
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