Ophiobolin-O Reverses Adriamycin Resistance via Cell Cycle Arrest and Apoptosis Sensitization in Adriamycin-Resistant Human Breast Carcinoma (MCF-7/ADR) Cells

Multidrug-resistance is a major obstacle facing cancer chemotherapy. This paper demonstrates that novel compound Ophiobolin-O reverses MCF-7/ADR resistance to adriamycin (ADM). The IC(50) of ADM treated MCF-7 cells was 2.02 ± 0.05 µM and 74.00 ± 0.18 µM treated MCF-7/ADR cells, about 37-fold, compar...

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Autors principals: Sun, Wenxia, Lv, Cuiting, Zhu, Tonghan, Yang, Xue, Wei, Shanjian, Sun, Jieyin, Hong, Kui, Zhu, Weiming, Huang, Caiguo
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853746/
https://ncbi.nlm.nih.gov/pubmed/24240979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md11114570
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