Asperolide A, a Marine-Derived Tetranorditerpenoid, Induces G2/M Arrest in Human NCI-H460 Lung Carcinoma Cells, Is Mediated by p53-p21 Stabilization and Modulated by Ras/Raf/MEK/ERK Signaling Pathway

Here we first demonstrate that asperolide A, a very recently reported marine-derived tetranorditerpenoid, leads to the inhibition of NCI-H460 lung carcinoma cell proliferation by G2/M arrest with the activation of the Ras/Raf/MEK/ERK signaling and p53-dependent p21 pathway. Treatment with 35 μM aspe...

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Main Authors: Lv, Cuiting, Sun, Wenxia, Sun, Haofen, Wei, Shanjian, Chen, Ruohua, Wang, Bingui, Huang, Caiguo
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640382/
https://ncbi.nlm.nih.gov/pubmed/23434831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md11020316
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