Silencing of the Tandem Pore Domain Halothane-inhibited K(+) Channel 2 (THIK2) Relies on Combined Intracellular Retention and Low Intrinsic Activity at the Plasma Membrane

The tandem pore domain halothane-inhibited K(+) channel 1 (THIK1) produces background K(+) currents. Despite 62% amino acid identity with THIK1, THIK2 is not active upon heterologous expression. Here, we show that this apparent lack of activity is due to a unique combination of retention in the endo...

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Detalhes bibliográficos
Main Authors: Chatelain, Franck C., Bichet, Delphine, Feliciangeli, Sylvain, Larroque, Marie-Madeleine, Braud, Véronique M., Douguet, Dominique, Lesage, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853260/
https://ncbi.nlm.nih.gov/pubmed/24163367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503318
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