Recombinant tandem of pore-domains in a Weakly Inward rectifying K(+) channel 2 (TWIK2) forms active lysosomal channels

Recombinant TWIK2 channels produce weak basal background K(+) currents. Current amplitudes depend on the animal species the channels have been isolated from and on the heterologous system used for their re-expression. Here we show that this variability is due to a unique cellular trafficking. We ide...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bobak, Nicole, Feliciangeli, Sylvain, Chen, Cheng-Chang, Ben Soussia, Ismail, Bittner, Stefan, Pagnotta, Sophie, Ruck, Tobias, Biel, Martin, Wahl-Schott, Christian, Grimm, Christian, Meuth, Sven G., Lesage, Florian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428834/
https://ncbi.nlm.nih.gov/pubmed/28381826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00640-8
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