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Tandem Pore Domain Halothane-inhibited K(+) Channel Subunits THIK1 and THIK2 Assemble and Form Active Channels

Despite a high level of sequence homology, tandem pore domain halothane-inhibited K(+) channel 1 (THIK1) produces background K(+) currents, whereas THIK2 is silent. This lack of activity is due to a unique combination of intracellular retention and weak basal activity in the plasma membrane. Here, w...

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Main Authors: Blin, Sandy, Chatelain, Franck C., Feliciangeli, Sylvain, Kang, Dawon, Lesage, Florian, Bichet, Delphine
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192476/
https://ncbi.nlm.nih.gov/pubmed/25148687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.600437
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