Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

Chemokines display considerable promiscuity with multiple ligands and receptors shared in common, a phenomenon that is thought to underlie their biochemical “redundancy.” Their receptors are part of a larger seven-transmembrane receptor superfamily, commonly referred to as G protein-coupled receptor...

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Bibliographic Details
Main Authors: Rajagopal, Sudarshan, Bassoni, Daniel L., Campbell, James J., Gerard, Norma P., Gerard, Craig, Wehrman, Tom S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853256/
https://ncbi.nlm.nih.gov/pubmed/24145037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479113
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