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Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer
BACKGROUND: T-cell immunoglobulin and mucin domain 3 (TIM-3) is known as a negative immune regulator and emerging data have implicated TIM-3 a pivotal role in suppressing antitumor immunity. The co-stimulatory receptor CD137 is transiently upregulated on T-cells following activation and increases th...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3853027/ https://ncbi.nlm.nih.gov/pubmed/24044888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-215 |
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