Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer

BACKGROUND: T-cell immunoglobulin and mucin domain 3 (TIM-3) is known as a negative immune regulator and emerging data have implicated TIM-3 a pivotal role in suppressing antitumor immunity. The co-stimulatory receptor CD137 is transiently upregulated on T-cells following activation and increases th...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Guo, Zhiqiang, Cheng, Dali, Xia, Zhijun, Luan, Meng, Wu, Liangliang, Wang, Gang, Zhang, Shulan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: BioMed Central 2013
विषय:
Research
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853027/
https://ncbi.nlm.nih.gov/pubmed/24044888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-215
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