Combinatorial PD-1 Blockade and CD137 Activation Has Therapeutic Efficacy in Murine Cancer Models and Synergizes with Cisplatin

There is an urgent need for improved therapy for advanced ovarian carcinoma, which may be met by administering immune-modulatory monoclonal antibodies (mAbs) to generate a tumor-destructive immune response. Using the ID8 mouse ovarian cancer model, we investigated the therapeutic efficacy of various...

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Hlavní autoři: Wei, Huafeng, Zhao, Likun, Li, Wei, Fan, Kexing, Qian, Weizhu, Hou, Sheng, Wang, Hao, Dai, Min, Hellstrom, Ingegerd, Hellstrom, Karl Erik, Guo, Yajun
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868659/
https://ncbi.nlm.nih.gov/pubmed/24367702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084927
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