Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

BACKGROUND: Cigarette smoking is the major risk factor for COPD, leading to chronic airway inflammation. We hypothesized that cigarette smoke induces structural and functional changes of airway epithelial mitochondria, with important implications for lung inflammation and COPD pathogenesis. METHODS:...

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Hlavní autoři: Hoffmann, Roland F, Zarrintan, Sina, Brandenburg, Simone M, Kol, Arjan, de Bruin, Harold G, Jafari, Shabnam, Dijk, Freark, Kalicharan, Dharamdajal, Kelders, Marco, Gosker, Harry R, ten Hacken, Nick HT, van der Want, Johannes J, van Oosterhout, Antoon JM, Heijink, Irene H
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852998/
https://ncbi.nlm.nih.gov/pubmed/24088173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-97
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