Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

BACKGROUND: Cigarette smoking is the major risk factor for COPD, leading to chronic airway inflammation. We hypothesized that cigarette smoke induces structural and functional changes of airway epithelial mitochondria, with important implications for lung inflammation and COPD pathogenesis. METHODS:...

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Main Authors: Hoffmann, Roland F, Zarrintan, Sina, Brandenburg, Simone M, Kol, Arjan, de Bruin, Harold G, Jafari, Shabnam, Dijk, Freark, Kalicharan, Dharamdajal, Kelders, Marco, Gosker, Harry R, ten Hacken, Nick HT, van der Want, Johannes J, van Oosterhout, Antoon JM, Heijink, Irene H
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852998/
https://ncbi.nlm.nih.gov/pubmed/24088173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-97
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