Synergistic growth inhibition by acyclic retinoid and phosphatidylinositol 3-kinase inhibitor in human hepatoma cells

BACKGROUND: A malfunction of RXRα due to phosphorylation is associated with liver carcinogenesis, and acyclic retinoid (ACR), which targets RXRα, can prevent the development of hepatocellular carcinoma (HCC). Activation of PI3K/Akt signaling plays a critical role in the proliferation and survival of...

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Bibliografiske detaljer
Main Authors: Baba, Atsushi, Shimizu, Masahito, Ohno, Tomohiko, Shirakami, Yohei, Kubota, Masaya, Kochi, Takahiro, Terakura, Daishi, Tsurumi, Hisashi, Moriwaki, Hisataka
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852533/
https://ncbi.nlm.nih.gov/pubmed/24103747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-465
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