SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

Sharpin-deficient mice display a multiorgan chronic inflammatory phenotype suggestive of altered leukocyte migration. We therefore studied the role of SHARPIN in lymphocyte adhesion, polarization and migration. We found that SHARPIN localizes to the trailing edges (uropods) of both mouse and human c...

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Detalhes bibliográficos
Main Authors: Pouwels, Jeroen, De Franceschi, Nicola, Rantakari, Pia, Auvinen, Kaisa, Karikoski, Marika, Mattila, Elina, Potter, Christopher, Sundberg, John P., Hogg, Nancy, Gahmberg, Carl G., Salmi, Marko, Ivaska, Johanna
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852511/
https://ncbi.nlm.nih.gov/pubmed/24210817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.10.011
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