Inclusion of CYP3A5 genotyping in a nonparametric population model improves dosing of tacrolimus early after transplantation

Following organ engraftment, initial dosing of tacrolimus is based on recipient weight and adjusted by measured C(0) concentrations. The bioavailability and elimination of tacrolimus are affected by the patients CYP3A5 genotype. Prospective data of the clinical advantage of knowing patient's CY...

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Autori principali: Åsberg, Anders, Midtvedt, Karsten, van Guilder, Mike, Størset, Elisabet, Bremer, Sara, Bergan, Stein, Jelliffe, Roger, Hartmann, Anders, Neely, Michael N
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2013
Soggetti:
Clinical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852421/
https://ncbi.nlm.nih.gov/pubmed/24118301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tri.12194
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