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Immuno-spin trapping of heme-induced protein radicals: Implications for heme oxygenase-1 induction and heme degradation

Heme, in the presence of hydrogen peroxide, can act as a peroxidase. Intravascular hemolysis results in a massive release of heme into the plasma in several pathophysiological conditions such as hemolytic anemia, malaria, and sickle cell disease. Heme is known to induce heme oxygenase-1(HO-1) expres...

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Bibliographic Details
Main Authors: Kumar, Ashutosh, Ganini, Douglas, Deterding, Leesa J., Ehrenshaft, Marilyn, Chatterjee, Saurabh, Mason, Ronald P.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851609/
https://ncbi.nlm.nih.gov/pubmed/23624303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.04.026
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