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Comparing CDRH3 diversity captured from secondary lymphoid organs for the generation of recombinant human antibodies

The plasticity of natural immunoglobulin repertoires can be exploited for the generation of phage display libraries. Secondary lymphoid organs, such as the spleen and the lymph nodes, constitute interesting sources of diversity because they are rich in B cells, part of which can be affinity matured....

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Bibliografski detalji
Glavni autori: Venet, Sophie, Kosco-Vilbois, Marie, Fischer, Nicolas
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851222/
https://ncbi.nlm.nih.gov/pubmed/23924800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25592
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