Elongation of the C-terminal domain of an anti-amyloid β single-chain variable fragment increases its thermodynamic stability and decreases its aggregation tendency

Lignende værker

• Early intervention in the 3xTg-AD mice with an amyloid β-antibody fragment ameliorates first hallmarks of Alzheimer disease
  af: Giménez-Llort, Lydia, et al.
  Udgivet: (2013)
• Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
  af: Michaels, Thomas C. T., et al.
  Udgivet: (2020)
• The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
  af: Valls-Comamala, Victòria, et al.
  Udgivet: (2017)
• Thermodynamics of Amyloid-β Fibril Elongation: Atomistic Details of the Transition State
  af: Rodriguez, Roberto A., et al.
  Udgivet: (2017)
• Loss of deep cerebellar nuclei neurons in the 3xTg-AD mice and protection by an anti-amyloid β antibody fragment
  af: Esquerda-Canals, Gisela, et al.
  Udgivet: (2013)