Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo

OBJECTIVE: Group IIa secretory phospholipase A2 (sPLA2 IIa) plays a role in the malignant potential of several epithelial cancers. Nuclear factor kappa B (NF-κB) regulates cancer cell growth and is modulated by phospholipase activity in many cancer cells. We hypothesized that knockdown of sPLA2 in l...

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Main Authors: Yu, Jessica A., Mauchley, David, Li, Howard, Meng, Xianzhong, Nemenoff, Raphael A., Fullerton, David A., Weyant, Michael J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850277/
https://ncbi.nlm.nih.gov/pubmed/23079010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtcvs.2012.08.003
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