Sulforaphane Potentiates the Efficacy of 17-Allylamino 17-Demethoxygeldanamycin Against Pancreatic Cancer Through Enhanced Abrogation of Hsp90 Chaperone Function

Heat shock protein 90 (Hsp90), an essential molecular chaperone that regulates the stability of a wide range of oncogenic proteins, is a promising target for cancer therapeutics. We investigated the combination efficacy and potential mechanisms of sulforaphane, a dietary component from broccoli and...

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Bibliographic Details
Main Authors: Li, Yanyan, Zhang, Tao, Schwartz, Steven J., Sun, Duxin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3850054/
https://ncbi.nlm.nih.gov/pubmed/21875325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/01635581.2011.596645
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