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(−)-Epigallocatechin-3-gallate Inhibits Hsp90 Function by Impairing Hsp90 Association with Co-chaperones in Pancreatic Cancer Cell Line Mia Paca-2
(−)-Epigallocatechin-3-gallate [(−)-EGCG], the most abundant polyphenolic catechin in green tea, showed chemoprevention and anticancer activities. (−)-EGCG was reported to bind to the C-terminal domain of heat shock protein 90 (Hsp90). The purpose of this study is to investigate (−)-EGCG as a novel...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732434/ https://ncbi.nlm.nih.gov/pubmed/19438225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900037p |
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