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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

The roles of IL-1R-associated kinase (IRAK)2 and IRAK1 in cytokine production were investigated using immune cells from knock-in mice expressing the TNFR-associated factor 6 (TRAF6) binding-defective mutant IRAK2[E525A] or the catalytically inactive IRAK1[D359A] mutant. In bone marrow-derived macrop...

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Bibliographic Details
Main Authors: Pauls, Eduardo, Nanda, Sambit K., Smith, Hilary, Toth, Rachel, Arthur, J. Simon C., Cohen, Philip
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849919/
https://ncbi.nlm.nih.gov/pubmed/23918981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203268
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