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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice
The roles of IL-1R-associated kinase (IRAK)2 and IRAK1 in cytokine production were investigated using immune cells from knock-in mice expressing the TNFR-associated factor 6 (TRAF6) binding-defective mutant IRAK2[E525A] or the catalytically inactive IRAK1[D359A] mutant. In bone marrow-derived macrop...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849919/ https://ncbi.nlm.nih.gov/pubmed/23918981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203268 |
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