Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

The roles of IL-1R-associated kinase (IRAK)2 and IRAK1 in cytokine production were investigated using immune cells from knock-in mice expressing the TNFR-associated factor 6 (TRAF6) binding-defective mutant IRAK2[E525A] or the catalytically inactive IRAK1[D359A] mutant. In bone marrow-derived macrop...

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Bibliographic Details
Main Authors:	Pauls, Eduardo, Nanda, Sambit K., Smith, Hilary, Toth, Rachel, Arthur, J. Simon C., Cohen, Philip
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3849919/ https://ncbi.nlm.nih.gov/pubmed/23918981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203268
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Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice

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