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Predictive and Prognostic Analysis of PIK3CA Mutation in Stage III Colon Cancer Intergroup Trial

BACKGROUND: Somatic mutations in PIK3CA (phosphatidylinositol-4,5-bisphosphonate 3-kinase [PI3K], catalytic subunit alpha gene) activate the PI3K-AKT signaling pathway and contribute to pathogenesis of various malignancies, including colorectal cancer. METHODS: We examined associations of PIK3CA onc...

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Detalhes bibliográficos
Main Authors: Ogino, Shuji, Liao, Xiaoyun, Imamura, Yu, Yamauchi, Mai, McCleary, Nadine J., Ng, Kimmie, Niedzwiecki, Donna, Saltz, Leonard B., Mayer, Robert J., Whittom, Renaud, Hantel, Alexander, Benson, Al B., Mowat, Rex B., Spiegelman, Donna, Goldberg, Richard M., Bertagnolli, Monica M., Meyerhardt, Jeffrey A., Fuchs, Charles S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848984/
https://ncbi.nlm.nih.gov/pubmed/24231454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djt298
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