Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E

BACKGROUND: Severe shortage of liver donors and hepatocytes highlights urgent requirement of extra-liver and stem cell source of hepatocytes for treating liver-related diseases. Here we hypothesized that spermatogonial stem cells (SSCs) can directly transdifferentiate to hepatic stem-like cells capa...

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Autors principals: Zhang, Zhenzhen, Gong, Yuehua, Guo, Ying, Hai, Yanan, Yang, Hao, Yang, Shi, Liu, Yang, Ma, Meng, Liu, Linhong, Li, Zheng, Gao, Wei-Qiang, He, Zuping
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848919/
https://ncbi.nlm.nih.gov/pubmed/24047406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-67
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