Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

BACKGROUND: Naphthoquinones (NQs) are privileged structures in medicinal chemistry due to the biological effects associated with the induction of oxidative stress. The present study evaluated the activities of sixteen NQs derivatives on Trypanosoma cruzi. RESULTS: Fourteen NQs displayed higher activ...

Full description

Saved in:
Bibliographic Details
Main Authors: Salomão, Kelly, De Santana, Natalia A, Molina, Maria Teresa, De Castro, Solange L, Menna-Barreto, Rubem F S
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848626/
https://ncbi.nlm.nih.gov/pubmed/24004461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-13-196
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items