Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

BACKGROUND: Naphthoquinones (NQs) are privileged structures in medicinal chemistry due to the biological effects associated with the induction of oxidative stress. The present study evaluated the activities of sixteen NQs derivatives on Trypanosoma cruzi. RESULTS: Fourteen NQs displayed higher activ...

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Main Authors: Salomão, Kelly, De Santana, Natalia A, Molina, Maria Teresa, De Castro, Solange L, Menna-Barreto, Rubem F S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848626/
https://ncbi.nlm.nih.gov/pubmed/24004461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-13-196
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