Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

BACKGROUND: Naphthoquinones (NQs) are privileged structures in medicinal chemistry due to the biological effects associated with the induction of oxidative stress. The present study evaluated the activities of sixteen NQs derivatives on Trypanosoma cruzi. RESULTS: Fourteen NQs displayed higher activ...

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Bibliografiske detaljer
Main Authors:	Salomão, Kelly, De Santana, Natalia A, Molina, Maria Teresa, De Castro, Solange L, Menna-Barreto, Rubem F S
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2013
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3848626/ https://ncbi.nlm.nih.gov/pubmed/24004461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-13-196
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Trypanosoma cruzi mitochondrial swelling and membrane potential collapse as primary evidence of the mode of action of naphthoquinone analogues

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