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Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes

BACKGROUND: Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar proteinosis (PAP) are deficient in activin A. PAP is an autoimmune lung diseas...

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Detalhes bibliográficos
Main Authors: Dalrymple, Heidi, Barna, Barbara P, Malur, Anagha, Malur, Achut G, Kavuru, Mani S, Thomassen, Mary Jane
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848434/
https://ncbi.nlm.nih.gov/pubmed/24044676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-14-41
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