Targeted PPARγ deficiency in alveolar macrophages disrupts surfactant catabolism

Surfactant accumulates in alveolar macrophages of granulocyte-macrophage colony-stimulating factor (GM-CSF) knockout (KO) mice and pulmonary alveolar proteinosis (PAP) patients with a functional loss of GM-CSF resulting from neutralizing anti–GM-CSF antibody. Alveolar macrophages from PAP patients a...

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Bibliografiske detaljer
Main Authors: Baker, Anna D., Malur, Anagha, Barna, Barbara P., Ghosh, Shobha, Kavuru, Mani S., Malur, Achut G., Thomassen, Mary Jane
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035495/
https://ncbi.nlm.nih.gov/pubmed/20064973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M001651
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