The phosphatidylinositol-3 kinase I inhibitor BKM120 induces cell death in B-chronic lymphocytic leukemia cells in vitro

BKM120, a pan class I PI3K inhibitor, was cytotoxic in the majority of primary B-chronic lymphocytic leukemia (CLL) lymphocytes, including samples from patients who have a high-risk for poor response to treatment (patient with del11 and del17) at clinically obtainable concentrations. The PI3Kδ inhib...

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Hlavní autoři: Amrein, Lilian, Shawi, May, Grenier, Jeremy, Aloyz, Raquel, Panasci, Lawrence
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847963/
https://ncbi.nlm.nih.gov/pubmed/23238639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27989
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